Dr. Klein pointed out that there is no obvious advantage to whole pelvis radiation. Dr. deKernion emphasized the long term side effects of ADT. Dr. Fradet in the audience stated that surgery does not necessarily mean higher morbidity than radiotherapy. Also, studies are not comparing the same cohorts of patients. Dr. Blute from the Mayo Clinic said that cancer-specific and overall survival is important and not PSA-free survival.

Dr. deKernion supported the clinical trials mentioned by Dr. Benson as providing the tissue necessary to perform molecular correlative studies. Dr. Sandler argued against the lumpectomy concept in that partial tumor removal is not of benefit.